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KMID : 1177720120060010031
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Journal of Alternatives to Animal Experiments
2012 Volume.6 No. 1 p.31 ~ p.34
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Irritation Test of Retinol and Kojic acid using Hen`s Egg Test-chorioallantoic Membrane(HET-CAM) Assay
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Kim Bae-Hwan
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Abstract
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The hen`s egg test-chorioallantoic membrane(HET-CAM) assay, an alternative method to eye irritation test, employs the vascular membrane of a fertile hen`s egg. Retinol has been usually used for topical treatment, because it has various effects such as anti-wrinkle and skin disorders. Kojic acid has been also extensively used for topical treatment, because it is well known for its anti-pigmentation effects cause by tyrosinase inhibition activities. In this study, we conducted irritation test of retinol using HET-CAM assay to compare with the result of Draize rabbit eye irritation test.
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KEYWORD
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HET-CAM, eye irritation test, retinol, kojic acid
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